Senior Scientist, Stem Cell Model Engineering( Contract)

Senior Scientist role focused on engineering genetically modified human induced pluripotent stem cell models to advance drug discovery and validation. The position involves developing complex cellular systems, troubleshooting technical challenges, and driving innovation within Amgen's Predictive Biology team in Burnaby, Canada.

Responsibilities

• Develop genetically engineered iPSC model systems including reporter, loss-of-function, and disease-relevant models
• Define and evaluate validation strategies to ensure engineered models meet downstream biological study requirements
• Identify, troubleshoot, and resolve technical and biological failures in cell engineering and differentiation
• Drive innovation by identifying workflow gaps and building new capabilities in stem cell model engineering
• Communicate technical risks, timelines, and model readiness through written and oral presentations

Requirements

• PhD in related discipline with 2+ years of experience, or MSc with 5+ years, or BSc with 8+ years
• Hands-on experience generating CRISPR-edited human iPSC models or similarly complex engineered cellular systems
• Strong experimental judgment in genome engineering strategy and model design and validation
• Practical understanding of failure modes in engineered iPSC models including clonal artifacts and expression instability
• Demonstrated scientific productivity evidenced by peer-reviewed publications and patents
• Strong communication and collaboration skills for multidisciplinary team environments

Compensation: $115,503–$156,269 CAD base