Engineer, Process Sciences - Upstream

Encoded Therapeutics is a clinical-stage genetic medicines company developing potentially disease-modifying therapies to improve the lives of people with severe CNS disorders. Our proprietary vector engineering approach combines novel regulatory elements and payloads with AAV vectors to unlock innovative solutions for debilitating, intractable CNS conditions. At the forefront is our flagship clinical program, ETX101 for Dravet syndrome, which targets the underlying cause of the disorder to enable highly selective upregulation ofSCN1Afor potentially long-lasting benefit. In parallel, we are advancing a pipeline of potentially best-in-class programs to address significant unmet needs across both monogenic and prevalent CNS conditions. For more information, please visit are recruiting an
Engineer, Process Sciences
to join our team. This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by a transformative core technology. The successful candidate will work well across multiple projects in a fast-paced and dynamic environment.Responsibilities
Design, execute, and analyze small-scale studies supporting the development of two at-scale products and Encoded’s pipeline productsServe as an engineer responsible for pre-clinical and clinical manufacturing for AAV projects and plasmid manufacturing;
including upstream, downstream, fill finish, and drug deviceFacilitate Encoded’s technology transfer of manufacturing processes to non-GMP/GMP internal and external sites of manufacturingProvide person-in-plant support of GMP (clinical and commercial) manufacturing as required at internal and external sites of manufacturingWork with cross-functional teams to develop tools/templates to support tech transfer business processesB.S or M.S. in a relevant area of specialization (biochemical engineering, chemical engineering, biological sciences, virology, molecular biology, or biochemistry)At least 3 years of industry experience or equivalent educational experienceAt least 1 year of industry experience in MSAT/PD/Process Sciences role preferredExtensive working knowledge of modern laboratory procedures and knowledge of cGMP is a mustAbility to independently design, execute, and analyze small-scale cell culture studies (cell expansion, single-use bioreactors, and harvest/clarification) is a mustMust be a team player and exhibit a willingness to meet project timelinesStrong verbal and written skills are required as well as effective interpersonal, technical, and troubleshooting skillsOutstanding planning, organization, and multitasking skillsExperience with gene therapy processes is strongly preferredComprehensive benefits package, including competitive employer premium contributionsMeaningful stock option grantsPTO, sick time, and holiday payGenerous Parental Leave programPre-tax medical and dependent care programsSTD, LTD, Life and AD&DProfessional development opportunitiesTeam-building eventsStocked micro-kitchen with drinks and snacksWellness ResourcesEncoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.
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