Bioinformatics Analyst

Job Description

Union: Non-Union

Number of Vacancies: 1

New or Replacement Position: Replacement

Site: Princess Margaret Cancer Centre

Department: Research

Reports to: Senior Scientist

Salary Range: $68,932 - $103,409 Per Year

Hours: Hours Per Week

Shifts: Day shifts

Status: Temporary Full-time

Closing Date: June 12, 2026

Position Summary

We are seeking an enthusiastic and highly motivated full-time Bioinformatics Analyst to join our team, initially on a contract basis with the possibility of transition to a permanent position. Our lab focuses on understanding how the bone marrow microenvironment shapes hematopoiesis and leukemia, with a strong emphasis on single‑cell and spatial approaches. The successful candidate will lead the computational analysis of single‑cell RNA‑seq, spatial transcriptomics, and T cell receptor (TCR) sequencing datasets, with a particular focus on integrating cellular states, clonal architecture, and spatial organization.

This is a highly collaborative research environment with access to unique human datasets and ongoing projects in leukemia and bone marrow biology. The position offers the opportunity to work at the interface of computation and biology and to contribute to high‑impact studies.

Duties

• Analyze and interpret single‑cell RNA‑seq, spatial transcriptomics, and TCR sequencing data
• Integrate multi‑modal datasets, including scRNA‑seq, spatial transcriptomics, TCR sequencing, and imaging data
• Perform cell‑cell interaction, niche, and clonotype analyses
• Link T cell clonality with transcriptional states
• Collaborate closely with experimental team members to guide study design and data interpretation
• Contribute to manuscripts and collaborative research projects

Qualifications

• Master’s degree in computational biology, Bioinformatics, or a related field
• Experience with single‑cell data analysis using Seurat, Scanpy, or similar tools
• Experience with TCR/BCR analysis is highly desirable
• Strong programming skills in R and/or Python
• Results‑driven, with a strong sense of ownership and the ability to efficiently advance analyses and projects
• Ability to work independently as well as collaboratively within a multidisciplinary team

Benefits

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including travel, restaurants, parking, phone plans, auto insurance discounts, on‑site gyms, etc.)

Equal Opportunity Employment

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.